Deep Well Plate & Tip Comb

SCILAB Deep Well Plates and Magnetic Tip Combs are a synergistic consumable system engineered for automated, high-throughput magnetic bead-based purification of nucleic acids (DNA/RNA) and proteins. The Deep Well Plate​ serves as the high-volume reaction vessel, while the Tip Comb (Magnetic Rod Sleeve) acts as the disposable magnetic probe that protects the instrument’s permanent magnets. Manufactured from high-purity, non-binding polypropylene, this system ensures maximum recovery and purity in automated extraction workflows.

Solving Key Lab Challenges:
• Enables High-Volume Processing with Standard Automation Footprint: The deep well plate maintains the standard SBS footprint (e.g., 96-well) while offering 0.36–2.3 mL working volumes per well, enabling large-scale binding and washing steps that are impossible in standard PCR plates. This is critical for processing low-concentration samples or scaling up plasmid preps.
• Protects Instrument Magnets and Prevents Cross-Contamination: The disposable tip comb forms a physical barrier between the expensive instrument magnet and the sample lysate. This prevents permanent magnet corrosion and eliminates carryover contamination between runs, which is essential for diagnostic and GLP environments.
• Optimizes Magnetic Bead Capture and Release for High Yield: The comb’s tip geometry is designed to create a concentrated magnetic field for efficient bead capture during the binding and wash phases. Its flexible, low-retention material ensures complete bead release during the final elution step, maximizing nucleic acid yield.
• Ensures Seamless Integration with Robotic Liquid Handlers: The plates feature full or semi-skirted designs for stability on robotic decks, and the tip combs are precision-molded to ensure perfect alignment and vertical travel within the deep wells, preventing crashes and ensuring reliable unattended operation.

Product Details

Description

Critical Applications:
• Automated Nucleic Acid Extraction (NAE): High-throughput purification of genomic DNA, viral RNA, and plasmid DNA using magnetic bead kits on platforms like KingFisher, Thermo Fisher, and Biomek.
• Next-Generation Sequencing (NGS) Library Prep: Cleanup and size selection of DNA fragments prior to sequencing, utilizing the high-volume capacity for bead-based cleanups.
• Protein Purification and Immunoprecipitation (IP): Capture of His-tagged proteins or antibody-antigen complexes using magnetic affinity beads.
• Cell-Free DNA (cfDNA) and Exosome Isolation: Processing large volumes of biofluids (serum, plasma) where high binding capacity is required.

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